Gene name:
LITAF (PIG7;SIMPLE) ;
Protein name:
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LPS-induced TNF-alpha factor) ;
Alternative:
p53-induced gene 7 protein ;Small integral membrane protein of lysosome/late endosome ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with NEDD4 (By similarity). Interacts with WWOX. Isoform 2 may interact with STAT6.
Function:
Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF-alpha) gene expression.
Subcellular Location:
Lysosome membrane
Peripheral membrane protein
Cytoplasmic side
Associated with membranes of lysosomes.
Protein Attributes:
50:
MSVPGPYQAA | TGPSSAPSAP | PSYEETVAVN | SYYPTPPAPM | PGPTTGLVTG |
100:
PDGKGMNPPS | YYTQPAPIPN | NNPITVQTVY | VQHPITFLDR | PIQMCCPSCN |
150:
KMIVSQLSYN | AGALTWLSCG | SLCLLGCIAG | CCFIPFCVDA | LQDVDHYCPN |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Chicken
Mouse
Rat
Human
ELISA Kit for Human LPS-induced TNF-alpha factor
ELISA Kit for Human LPS-induced TNF-alpha factor
ELISA Kit for Human LPS-induced TNF-alpha factor
ELISA Kit for Human LPS-induced TNF-alpha factor
CLIA Kit for Human LPS-induced TNF-alpha factor
CLIA Kit for Human LPS-induced TNF-alpha factor
CLIA Kit for Human LPS-induced TNF-alpha factor
CLIA Kit for Human LPS-induced TNF-alpha factor
Polyclonal Antibody for Human LPS-induced TNF-alpha factor
Polyclonal Antibody for Human LPS-induced TNF-alpha factor
Polyclonal Antibody for Human LPS-induced TNF-alpha factor
Polyclonal Antibody for Human LPS-induced TNF-alpha factor
Monoclonal Antibody for Human LPS-induced TNF-alpha factor
Monoclonal Antibody for Human LPS-induced TNF-alpha factor
Monoclonal Antibody for Human LPS-induced TNF-alpha factor
Monoclonal Antibody for Human LPS-induced TNF-alpha factor
Protein for Human LPS-induced TNF-alpha factor
Protein for Human LPS-induced TNF-alpha factor
Protein for Human LPS-induced TNF-alpha factor
Protein for Human LPS-induced TNF-alpha factor
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;INDUCTION;SUBCELLULAR LOCATION
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue :
Hair follicle dermal papilla .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Esophageal carcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Kidney .
tissue :
Pancreas .
tissue :
PNS .
tissue :
Skin .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH WWOX;DOMAIN;MUTAGENESIS OF TYR-23 AND TYR-61
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH STAT6
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS CMT1C SER-112; ASN-115 AND GLY-116
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT EMPD HIS-23
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT CMT1C SER-112;VARIANT VAL-92
14.
"SIMPLE mutations in Charcot-Marie-Tooth disease and the potential role of its protein product in protein degradation."
Saifi G.M.
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Szigeti K.
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Wiszniewski W.
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Shy M.E.
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Krajewski K.
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Hausmanowa-Petrusewicz I.
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Kochanski A.
,
Reeser S.
,
Mancias P.
,
Butler I.
,
Lupski J.R.
Hum. Mutat.25:372-383(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS CMT1C MET-49; SER-112 AND VAL-122;VARIANT VAL-92